Lesson Summary: In this lesson, students applied their knowledge of microorganisms by designing and creating a board game that explores their beneficial and harmful effects, fostering real-world connections and higher-order thinking. The lesson began with a review of microorganisms, including their roles in health, food production, and disease. Students worked in small groups to brainstorm ideas for a board game that would teach players about microorganisms while being fun and interactive. They planned game mechanics, such as question cards, challenges, or movement spaces, to incorporate facts about beneficial microorganisms, like probiotics, and harmful ones, such as pathogens. Groups then designed their game boards, created rules, and developed content, including trivia questions or scenarios that required players to apply their understanding. Once completed, students played each other’s games, testing their designs and providing feedback. This project encouraged creativity, collaboration, and the practical application of scientific concepts, demonstrating how microorganisms impact everyday life.